RT Journal Article
SR Electronic
T1 EVALUATION OF VARIOUS ADRENERGIC BLOCKING AGENTS IN ISOLATED RABBIT AND TURTLE HEARTS
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 34
OP 40
VO 150
IS 1
A1 Walter D. Meester
A1 Harold F. Hardman
A1 Joseph J. Barboriak
YR 1965
UL http://jpet.aspetjournals.org/content/150/1/34.abstract
AB The effects of various adrenergic blocking agents on the cardiac positive inotropic action of epinephrine were studied in isolated perfused rabbit and turtle hearts. Some of the newer adrenergic blocking agents, including pronethalol (PRON), the N-isopropyl and n-butyl derivatives of p-nitrophenylethanolamine (INPEA and BNPEA, respectively) and N-isopropylmethoxamine (IMA) were compared with dichloroisoproterenol (DCI). It was found that under the conditions of this study, all of these agents possess beta adrenergic receptor blocking activity in rabbit and turtle hearts. DCI and pronethalol were approximately equieffective and superior in their blocking ability to the other compounds tested. INPEA provided better blockade of the positive inotropic action of epinephrine than BNPEA and IMA, both of which possessed only weak beta blocking action. The Williams & Wilkins Comapny