TY - JOUR T1 - EVALUATION OF VARIOUS ADRENERGIC BLOCKING AGENTS IN ISOLATED RABBIT AND TURTLE HEARTS JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 34 LP - 40 VL - 150 IS - 1 AU - Walter D. Meester AU - Harold F. Hardman AU - Joseph J. Barboriak Y1 - 1965/10/01 UR - http://jpet.aspetjournals.org/content/150/1/34.abstract N2 - The effects of various adrenergic blocking agents on the cardiac positive inotropic action of epinephrine were studied in isolated perfused rabbit and turtle hearts. Some of the newer adrenergic blocking agents, including pronethalol (PRON), the N-isopropyl and n-butyl derivatives of p-nitrophenylethanolamine (INPEA and BNPEA, respectively) and N-isopropylmethoxamine (IMA) were compared with dichloroisoproterenol (DCI). It was found that under the conditions of this study, all of these agents possess beta adrenergic receptor blocking activity in rabbit and turtle hearts. DCI and pronethalol were approximately equieffective and superior in their blocking ability to the other compounds tested. INPEA provided better blockade of the positive inotropic action of epinephrine than BNPEA and IMA, both of which possessed only weak beta blocking action. The Williams & Wilkins Comapny ER -