RT Journal Article
SR Electronic
T1 EVIDENCE FOR BETA RECEPTORS IN THE RAT MESENTERIC MICROVASCULATURE
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 23
OP 25
VO 150
IS 1
A1 Burton M. Altura
A1 Benjamin W. Zweifach
YR 1965
UL http://jpet.aspetjournals.org/content/150/1/23.abstract
AB Experiments were designed to establish the effect of dichloroisoproterenol (DCI) on the peripheral microvasculature of the rat mesocecum. The microcirculatory effects of DCI were documented by direct microscopic visualization of the response to locally applied catecholamines, as well as histamine and serotonin. Administration of DCI (10 mg/kg) produced a marked transient venular constriction (which disappeared in 2 to 5 minutes) and an increase in vascular reactivity to locally applied constrictor catecholamines while blocking the local vasodilator action of isoproterenol. On the basis of time selective blockade, by DCI, of the dilator effects of isoproterenol andtime enhancement of venular constrictor action in comparison to time amount of arteriolar constriction to locally applied epinephrine and norepinephrine, it is concluded that beta type receptors exist in the rat mesenteric microcirculation. The Williams & Wilkins Comapny