RT Journal Article
SR Electronic
T1 ALPHA AND BETA ADRENERGIC RECEPTOR MECHANISMS IN THE SYSTEMIC VENOUS BED
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 156
OP 162
VO 144
IS 2
A1 Kaiser, Gerard A.
A1 Ross, John
A1 Braunwald, Eugene
YR 1964
UL http://jpet.aspetjournals.org/content/144/2/156.abstract
AB The effects of isoproterenol, phenylephrine, and norepinephrine were studied in an experimental canine preparation in which cardio-pulmonary bypass permitted exclusion of the heart and lungs, and allowed continuous measurement of alterations of intravascular blood volume. In all experiments the beta adrenergic receptor stimulator, isoproterenol, resulted in a decrease in systemic vascular blood volume, similar to that observed with the alpha receptor stimulating agents, phenylephrine and norepinephrine. By the use of appropriate adrenergic blocking agents, it was demonstrated that the systemic venous bed contains both beta and alpha adrenergic receptors. Thus, in contrast to the opposing actions of these receptors in the arterial bed, stimulation of either alpha or beta receptors produces venoconstriction. The Williams & Wilkins Company