PT  - JOURNAL ARTICLE
AU  - Kaiser, Gerard A.
AU  - Ross, John
AU  - Braunwald, Eugene
TI  - ALPHA AND BETA ADRENERGIC RECEPTOR MECHANISMS IN THE SYSTEMIC VENOUS BED
DP  - 1964 May 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 156--162
VI  - 144
IP  - 2
4099  - http://jpet.aspetjournals.org/content/144/2/156.short
4100  - http://jpet.aspetjournals.org/content/144/2/156.full
SO  - J Pharmacol Exp Ther1964 May 01; 144
AB  - The effects of isoproterenol, phenylephrine, and norepinephrine were studied in an experimental canine preparation in which cardio-pulmonary bypass permitted exclusion of the heart and lungs, and allowed continuous measurement of alterations of intravascular blood volume. In all experiments the beta adrenergic receptor stimulator, isoproterenol, resulted in a decrease in systemic vascular blood volume, similar to that observed with the alpha receptor stimulating agents, phenylephrine and norepinephrine. By the use of appropriate adrenergic blocking agents, it was demonstrated that the systemic venous bed contains both beta and alpha adrenergic receptors. Thus, in contrast to the opposing actions of these receptors in the arterial bed, stimulation of either alpha or beta receptors produces venoconstriction. The Williams & Wilkins Company