PT  - JOURNAL ARTICLE
AU  - Thomas N. James
AU  - Reginald A. Nadeau
TI  - THE CHRONOTROPIC ACTION OF TYRAMINE STUDIED BY DIRECT PERFUSION OF THE SINUS NODE THROUGH ITS ARTERY
DP  - 1964 Apr 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 83--88
VI  - 144
IP  - 1
4099  - http://jpet.aspetjournals.org/content/144/1/83.short
4100  - http://jpet.aspetjournals.org/content/144/1/83.full
SO  - J Pharmacol Exp Ther1964 Apr 01; 144
AB  - Tyramine injected into the sinus node artery produces more tachycardia (both in peak level and duration) in normal than in reserpinized dogs. The duration of sinus tachycardia from tyramine is much longer than that from norepinephnine administered in the same manner. The responsiveness to tyramine by the sinus node of reserpinized dogs can be transiently restored to normal with norepinephrine, hut not by isoproterenol. Norepinephrine injected into the sinus node artery of reserpinized dogs does not restore the accelerative response to stimulation of the stellate ganglion. The Williams & Wilkins Company