TY - JOUR T1 - INHIBITION OF URIC ACID BIOSYNTHESIS IN THE CHICK EMBRYO AND CHICKEN BY A XANTHINE OXIDASE INHIBITOR, 4-HYDROXYPYRAZOLO(3,4d)PYRIMIDINE JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 417 LP - 422 VL - 149 IS - 3 AU - Irwin H. Krakoff AU - Richard L. Meyer Y1 - 1965/09/01 UR - http://jpet.aspetjournals.org/content/149/3/417.abstract N2 - Allopurinol, an inhibitor of xanthine oxidase, can markedly inhibit uric acid production in the developing chick embryo, the growing chick and in adult chickens at doses which produce little toxicity. The diversion of nitrogen from the usual end-product, uric acid, to a different nitrogenous end product, continued over a period of several days, is consistent in the chick embryo and chick, with normal development and growth. The Williams & Wilkins Comapny ER -