RT Journal Article
SR Electronic
T1 A COMPARISON OF THE RESPONSES TO <em>l</em>-SPARTEINE AND OXYTOCIN IN ISOLATED HUMAN UTERINE MUSCLES
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 138
OP 141
VO 144
IS 1
A1 Rosenblum, Ira
A1 Stein, Arthur A.
YR 1964
UL http://jpet.aspetjournals.org/content/144/1/138.abstract
AB Comparisons have been made between the effects of l-sparteine and oxytocin on isolated human uterine muscles. Both drugs can initiate spontaneous contractions and this effect is antagonized by addition of medroxyprogesterone to the fluid bath. Neither l-sparteine nor oxytocin could initiate spontaneous contractions in muscles "polaized" in K2SO4-Ringer solution. These findings suggest that l-sparteine has its main action on membrane function rather than directly on the contractile elements of uterine muscle. The Williams &amp; Wilkins Company