PT  - JOURNAL ARTICLE
AU  - J. D. Welty
AU  - W. O. Read
TI  - STUDIES ON SOME CARDIAC EFFECTS OF TAURINE
DP  - 1964 Apr 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 110--115
VI  - 144
IP  - 1
4099  - http://jpet.aspetjournals.org/content/144/1/110.short
4100  - http://jpet.aspetjournals.org/content/144/1/110.full
SO  - J Pharmacol Exp Ther1964 Apr 01; 144
AB  - Experiments were performed to determine the effect of taurine on the intracellular potassium of heart tissue. The data show that: (1) taurine, in the presence of 10-6 M epinephrine or 1.25 x 10-6 M digoxin, promotes cellular accumulation of potassium in heart slices and abolishes or reverses the loss of cell potassium when heart slices are incubated in the presence of 10-4 M epinephrine or 1.25 x 10-4 M digoxin; (2) epinephnine, digoxin and procaine amide increase the conversion of taunine to isethionic acid by heart slices, quinidine has no effect, while acetylcholine depresses the conversion; (3) taurine, in the intact dog heart, prevents the efflux of potassium which accompanies lange doses of epinephrine. The Williams & Wilkins Company