PT - JOURNAL ARTICLE AU - Albert B. Craig, Jr. TI - VASCULAR AND METABOLIC EFFECTS OF EPINEPHRINE IN THE ISOLATED PERFUSED RAT LIVER DP - 1965 Sep 01 TA - Journal of Pharmacology and Experimental Therapeutics PG - 346--350 VI - 149 IP - 3 4099 - http://jpet.aspetjournals.org/content/149/3/346.short 4100 - http://jpet.aspetjournals.org/content/149/3/346.full SO - J Pharmacol Exp Ther1965 Sep 01; 149 AB - The vascular responses of the isolated perfused rat liver to epinephrine were found to be very similar to that organ's response in vivo, namely a prompt and (lose-dependent vaso-constriction which reduces blood flow. This effect of epinephrine could be blocked or reversed by dihydroergotamine. By contrast, drug-induced potassium and glucose losses from the perfused organ are slow and are less than those which might be expected from this organ in vivo. The Williams & Wilkins Comapny