RT Journal Article
SR Electronic
T1 ABSORPTION, METABOLISM AND ELIMINATION OF THIABENDAZOLE IN FARM ANIMALS AND A METHOD FOR ITS ESTIMATION IN BIOLOGICAL MATERIALS
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 263
OP 271
VO 149
IS 2
A1 Dominick J. Tocco
A1 John R. Egerton
A1 William Bowers
A1 Victoria W. Christensen
A1 Charles Rosenblum
YR 1965
UL http://jpet.aspetjournals.org/content/149/2/263.abstract
AB Radioactive thiabendazole administered orally to farm animals (goats, cattle and swine) as single doses of 50 to 200 mg/kg was rapidly absorbed and metabolized, and effectively excreted. In these animals the only known metabolites are 5-hydroxythiabendazole and its glucuronide or sulfate ester. A spectrophoto-fluorometric procedure for the estimation of these compounds in biological fluids and tissues is presented. The analytical procedure accounted nearly quantitatively for the radioactivity present in the urine. Peak concentrations in plasma occurred 4 to 7 hours after dosage after which the concentrations decreased rapidly. Approximately 85% of the radioactivity was eliminated in the urine (65%) and feces (20%) in 3 days. No residual thiabendazole or metabolites were detectable in tissue 30 days after administration of 50 mg/kg. Traces of nonthiabendazole radioactivity were barely demonstrable in calves 2 months following doses of 150 and 200 mg/kg. Small quantities of the drug appeared in the milk of lactating animals. In goats less than 1%, and in dairy cows about 0.1% of the dose was secreted in the milk and peak drug concentrations were found within 24 hours after dosage. Nearly all of the drug was metabolized thiabendazole—only trace quantities of the unchanged compound were present. Thiabendazole and its metabolites were not detectable in the milk 4 days after goats were given a dose of 150 mg/kg or 60 hours after cows were given 220 mg/kg. The Williams & Wilkins Comapny