TY - JOUR T1 - THE EFFECTS OF RESERPINE PRETREATMENT ON THE <span class="sc">D</span>- AND <span class="sc">L</span>-ISOMERS OF SOME SYMPATHOMIMETIC AMINES JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 199 LP - 205 VL - 149 IS - 2 AU - Popat N. Patil AU - A. Tye AU - J. B. Lapidus Y1 - 1965/08/01 UR - http://jpet.aspetjournals.org/content/149/2/199.abstract N2 - Blood pressure and nictitating membrane effects of the D- and L- isomers of norepinephrine, epinephrine, cobefrin, phenylephrine and octopamine were studied in spinal cats. The responses obtained in reserpine-treated animals were compared to those obtained in control animals. The pressor effects of D(-)-norepineophrine, L(+)-norepinephrine, D(-)-epinephrine, L(+)-epinephrine, D(-)-cobefrin, D(-)- phenylephrine, and D(-)-octopamine were mainly direct in nature, while L(+)-cobefrin, L(+)-phenylephrine, and L(+)-octopamine exhibited a considerable component of indirect activity. A similar pattern also was observed in nictitating membrane with the exception that D(-)-octopamine exhibited some indirect activity on this effector organ. The effect of spatial configuration in relation to direct and indirect action is discussed. The importance of the D-or a-configuration at the beta carbon and its relation to "direct" activity is emphasized. The Williams &amp; Wilkins Comapny ER -