RT Journal Article
SR Electronic
T1 PHARMACOLOGICAL AND TOXICOLOGICAL PROPERTIES OF TWO NEW β-ADRENERGIC RECEPTOR ANTAGONISTS
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 161
OP 173
VO 149
IS 2
A1 P. M. Lish
A1 J. H. Weikel
A1 K. W. Dungan
YR 1965
UL http://jpet.aspetjournals.org/content/149/2/161.abstract
AB Studies involving the responses of respiratory and uterine smooth muscle and cardiac muscle to isoproterenol have revealed potent and selective β-adrenergic blocking action as a property of two phenethanolamine compounds bearing a methylsulfonamido radical at the para position on the benzene ring. These compounds had no other significant peripheral actions, including no local anesthetic action, and only limited effects on the central nervous system. Acute toxicity studies in mice, rats, dogs, and rabbits, and subacute toxicity studies in rats and dogs, indicated extremely low toxic liability. Neither compound had harmful effects on the fetuses of mice or rabbits dosed during critical days of pregnancy. The Williams & Wilkins Comapny