TY - JOUR T1 - EFFECT OF DRUGS ON THE UPTAKE, RELEASE, AND METABOLISM OF H<sup>3</sup>-NOREPINEPHRINE IN THE RAT BRAIN JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 43 LP - 49 VL - 149 IS - 1 AU - Jacques Glowinski AU - Julius Axelrod Y1 - 1965/07/01 UR - http://jpet.aspetjournals.org/content/149/1/43.abstract N2 - The effects of drugs and metabolic inhibitors on the uptake, release and metabolism of intraventricularly administered H3-norepinephnine in the rat brain are described. Amphetamine, reserpine and guanethidine, but not cocaine, D-lysergic acid diethylamide, mescaline or bretylium, block the uptake or accumulation of H3-norepinephrine in the brain. Monoamine oxidase inhibition produces an elevation of H3-norepinephrine and H3-normetanephrine in the brain. A catechol O-methyl transferase inhibitor, tropolone-4-acetamide, reduces the level of H3-normetanephrine but has no effect on the level of H3-norepinephrine. Amphetamine and reserpine release H3-norepinephrine in a different manner. Amphetamine administration results in an elevation of normetanephrine levels, while reserpine administration causes an elevation of O-methylated deaminated metabolites. Both drugs release a greater proportion of the brain content of H3-norepinephrine when they are administered a long time after the injection of the radioactive catecholamine than after a short time. The different actions of amphetamine and reserpine on the metabolism of H3-norepinephrine indicate the presence of more than one storage form of the brain catecholamine. The Williams &amp; Wilkins Comapny ER -