PT - JOURNAL ARTICLE AU - E. S. Boyd AU - D. A. Meritt TI - EFFECTS OF THIOPENTAL AND A TETRAHYDROCANNABINOL DERIVATIVE ON AROUSAL AND RECRUITING IN THE CAT DP - 1965 Jul 01 TA - Journal of Pharmacology and Experimental Therapeutics PG - 138--145 VI - 149 IP - 1 4099 - http://jpet.aspetjournals.org/content/149/1/138.short 4100 - http://jpet.aspetjournals.org/content/149/1/138.full SO - J Pharmacol Exp Ther1965 Jul 01; 149 AB - Thiopental, 2 mg/kg, and DMHP, 0.2 mg/kg, increased the threshold for EEG arousal in acute preparations, and for behavioral, as well as EEG, arousal in chronic preparations. Arousal was induced in all preparations by electrical stimulation of the reticular formation. It is suggested that some responses following thiopental, such as cortical desynchronization from the drug and synchrony instead of asynchrony during stimulation, as well as occasional initial lowering of threshold for arousal by both thiopental and DMHP, may be explained on the basis of an ascending inhibitory reticular system. An attempt to produce EEG and behavioral arousal by the selective circulation of thiopental to the pontomedullary region in chronically prepared animals was successful in only 2 of 8 preparations. Thiopental, 5 to 10 mg/kg, and DMHP, 0.2 mg/kg, had no effect on the recruiting response. The Williams & Wilkins Comapny