RT Journal Article
SR Electronic
T1 CARDIOVASCULAR AND METABOLIC INTERRELATIONSHIPS BETWEEN THYROXINE AND THE SYMPATHETIC NERVOUS SYSTEM
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 290
OP 297
VO 148
IS 3
A1 Marilyn E. Hess
A1 Joseph Shanfeld
YR 1965
UL http://jpet.aspetjournals.org/content/148/3/290.abstract
AB In rats, the administration of thyroxine or triiodothyronine caused an increase in cardiac phosphorylase a activity which was concomitant with an elevation in mean arterial blood pressure and an increase in heart rate. The cardiovascular stimulation and increase in phosphorylase activity observed after intravenous injection of epinephrine were not potentiated by prior intramuscular administration of thyroxine. Acetylcholine or pronethalol reversed the thyroxine-induced elevation of heart phosphorylase a activity and heart rate; reserpine inhibited the increase in cardiac phosphorylase a activity and the cardiovascular stimulation seen with thyroxine administration. The Williams & Wilkins Comapny