RT Journal Article
SR Electronic
T1 SUBCELLULAR DISTRIBUTION OF SOME SYMPATHOMIMETIC AMINES AND THEIR β-HYDROXYLATED DERIVATIVES IN THE RAT HEART
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 22
OP 28
VO 148
IS 1
A1 Jose M. Musacchio
A1 Irwin J. Kopin
A1 Virginia K. Weise
YR 1965
UL http://jpet.aspetjournals.org/content/148/1/22.abstract
AB The subcellular distribution of tyramine, α- methyltyramine, m-tyramine, dopamine and their β-hydroxylated derivatives has been studied in the rat heart. Tyramine, α-methyltyramine and m-tyramine can enter the microsomal fraction but are not retained. Octopamine, α-methyloctopamine, m- octopamine, dopamine and norepinephrine are distributed differently between microsomal and soluble fractions. The presence of a catechol group results in greater retention in the microsomal fraction than does the β-hydroxyl group. Sympathomimetic amines which lack both the catechol and β-hydroxyl group do not stay in the microsomal fraction. Norepinephrine, which contains both, is most efficiently retained in the particulate fraction. Retention in the microsomal fraction isolated from tissue homogenates parallels retention of the amine after administration of tyramine or guanethidine. The Williams & Wilkins Comapny