RT Journal Article SR Electronic T1 THE INFLUENCE OF CHOLINERGIC AND ANTICHOLINERGIC DRUGS ON EGG DEPOSITION BY A ROTIFER JF Journal of Pharmacology and Experimental Therapeutics JO J Pharmacol Exp Ther FD American Society for Pharmacology and Experimental Therapeutics SP 123 OP 128 VO 146 IS 1 A1 Lewis A. Lindner A1 Harold Goldman YR 1964 UL http://jpet.aspetjournals.org/content/146/1/123.abstract AB The response of an infra-annelid metazoan to agents which affect acetylcholine systems in more advanced organisms has been studied. Most notably, acetylcholine reversibly blocks egg deposition by the bdelloid rotifer Philodina acuticornis at an ED50 concentration of 6 x 10-5 M; no other gross functional or structural effects were noted up to lethal concentrations, 6 x 10-2 M. Physostigmine and neostigmine neither blocked egg deposition nor augmented the effect of acetylcholine; on the contrary, these two drugs, as well as atropine, tubocurarine, succinylcholine, and local anesthetics, decreased the egg retention produced by acetylcholine. The Williams & Wilkins Comapny