TY - JOUR T1 - THE EFFECT OF SEVERAL PHARMACOLOGICAL AGENTS UPON RB<sup>86</sup> UPTAKE BY THE PERFUSED DOG HINDLIMB JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 117 LP - 122 VL - 146 IS - 1 AU - Lloyd P. Gabel AU - Martin M. Winbury AU - Howard Rowe AU - Robert P. Grandy Y1 - 1964/10/01 UR - http://jpet.aspetjournals.org/content/146/1/117.abstract N2 - A technique utilizing the perfused canine hindlimb for studies of vascular resistance, % Rb86 uptake and oxygen uptake has been described. Agents which caused directionally similar alterations in vascular resistance differ in their effect on % Rb86 uptake. Among the vasoconstrictors, epinephrine and norepinephrine increased Rb86 uptake whereas vasopressin decreased Rb86 uptake. Among the vasodilators, histamine, nitroglycerin and pentaerythritol tetranitrate increased Rb86 uptake whereas acetylcholine decreased Rb86 uptake. Alterations in oxygen uptake always qualitatively followed the changes in % Rb86 uptake. Local hypoxia decreased vascular resistance and increased Rb86 uptake. Shock produced by hemorrhage or epinephrine infusion increased vascular resistance and decreased Bb86 uptake. Dose-response rebated changes in both vascular resistance and % Rb86 uptake to intraarterial injection of epinephrine and histamine were demonstrated. The Williams &amp; Wilkins Comapny ER -