PT  - JOURNAL ARTICLE
AU  - Harris, Louis S.
AU  - Pierson, Anne K.
TI  - SOME NARCOTIC ANTAGONISTS IN THE BENZOMORPHAN SERIES
DP  - 1964 Feb 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 141--148
VI  - 143
IP  - 2
4099  - http://jpet.aspetjournals.org/content/143/2/141.short
4100  - http://jpet.aspetjournals.org/content/143/2/141.full
SO  - J Pharmacol Exp Ther1964 Feb 01; 143
AB  - Four members of a new series of analgesic antagonists in the 6,7-benzomorphan series have been described. A quantitative method for the assessment of analgesic-antagonistic potency in the rat has been outlined. Using this method two of the compounds, 2-allyl-5-ethyl-2'-hydroxy-9-methyl-6,7-benzomorphan (I) and 2-cyclopropylmethyl-2' - hydroxy - 5,9 - dimethyl - 6,7 - benzomorphan (IV), were found to be potent antagonists. The other two, 2-(3,3-dimethylallyl 2-(3,3-di-methylallyl)-2'-2'-hydroxy-5,9-dimethyl-6,7-benzomorphan (II) and 2-(3,3 - dimethylallyl) - 5 - ethyl - 2' - hydroxy-9-methyl-6,7-benzomorphan (III), were found to be weak antagonists. Compound IV was also found to have important central muscle-relaxant, anticonvulsant, and tranquilizing properties. Again, a separation appears to have been made between analgesic activity and addiction liability. The Williams & Wilkins Company