PT - JOURNAL ARTICLE AU - Charles B. Smith TI - ENHANCEMENT BY RESERPINE AND α-METHYL DOPA OF THE EFFECTS OF <em>d</em>-AMPHETAMINE UPON THE LOCOMOTOR ACTIVITY OF MICE DP - 1963 Dec 01 TA - Journal of Pharmacology and Experimental Therapeutics PG - 343--350 VI - 142 IP - 3 4099 - http://jpet.aspetjournals.org/content/142/3/343.short 4100 - http://jpet.aspetjournals.org/content/142/3/343.full SO - J Pharmacol Exp Ther1963 Dec 01; 142 AB - Changes in the effect of d-amphetamine upon locomotor activity of grouped mice caused by reserpine or by α-methyl dopa depended upon the time which elapsed between the injection of reserpine or α-methyl dopa and the injection of d-amphetamine. Following treatment of mice with reserpine or α-methyl dopa a marked enhancement of the activity-increasing effect of d-amphetamine occurred. The activity-increasing effect of cocaine and of pipradrol was not enhanced after reserpine, indicating a specific action of reserpine upon the effect of d-amphetamine. The enhancement of the activity-increasing effect of d-amphetamine after α-methyl dopa followed changes in brain norepinephrine more closely than changes in either brain 5-HT or dopamine. The activity-increasing effect of l-dopa was also enhanced after α-methyl dopa. These experiments suggest that in the central nervous system d-amphetamine acts primarily as a direct-acting sympathomimetic amine although some indirect action cannot be excluded. The Williams &amp; Wilkins Company