TY - JOUR T1 - INFLUENCE OF ISOPROTERENOL AND 1-(2',4'-DICHLOROPHENYL)-2-t-BUTYLAMINOETHANOL (DCB) ON FREE FATTY ACID RELEASE AND GLUCOSE METABOLISM IN ADIPOSE TISSUE JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 137 LP - 140 VL - 142 IS - 2 AU - William C. Love AU - Lucinda Carr AU - James Ashmore Y1 - 1963/11/01 UR - http://jpet.aspetjournals.org/content/142/2/137.abstract N2 - Free fatty acid release, glucose uptake and the incorporation of C14 from specifically labeled glucose into CO2, glyceride-glycerol and fatty acids by rat epididymal adipose tissue in vitro has been studied. The influence of isoproterenol and a blocking agent dl-1-(2',4'-dichlorophenyl)-2-t-butylaminoethanol (DCB) on these metabolic functions has been examined. Isoproterenol increased free fatty acid release and produced a pattern of glucose metabolism in this tissue similar to that produced by epinephrine and norepinephrine. DCB, which does not stimulate free fatty acid release, stimulated glucose utilization though not as markedly as isoproterenol. DCB inhibited the release of free fatty acids by adipose tissue exposed to isoproterenol and reduced the effects of the latter compound on glucose metabolism. The Williams & Wilkins Company ER -