PT  - JOURNAL ARTICLE
AU  - William C. Love
AU  - Lucinda Carr
AU  - James Ashmore
TI  - INFLUENCE OF ISOPROTERENOL AND 1-(2',4'-DICHLOROPHENYL)-2-t-BUTYLAMINOETHANOL (DCB) ON FREE FATTY ACID RELEASE AND GLUCOSE METABOLISM IN ADIPOSE TISSUE
DP  - 1963 Nov 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 137--140
VI  - 142
IP  - 2
4099  - http://jpet.aspetjournals.org/content/142/2/137.short
4100  - http://jpet.aspetjournals.org/content/142/2/137.full
SO  - J Pharmacol Exp Ther1963 Nov 01; 142
AB  - Free fatty acid release, glucose uptake and the incorporation of C14 from specifically labeled glucose into CO2, glyceride-glycerol and fatty acids by rat epididymal adipose tissue in vitro has been studied. The influence of isoproterenol and a blocking agent dl-1-(2',4'-dichlorophenyl)-2-t-butylaminoethanol (DCB) on these metabolic functions has been examined. Isoproterenol increased free fatty acid release and produced a pattern of glucose metabolism in this tissue similar to that produced by epinephrine and norepinephrine. DCB, which does not stimulate free fatty acid release, stimulated glucose utilization though not as markedly as isoproterenol. DCB inhibited the release of free fatty acids by adipose tissue exposed to isoproterenol and reduced the effects of the latter compound on glucose metabolism. The Williams & Wilkins Company