RT Journal Article
SR Electronic
T1 CHRONOTROPIC AND VAGAL-BLOCKING EFFECTS OF DCI STUDIED BY DIRECT PERFUSION OF THE SINUS NODE
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 73
OP 78
VO 140
IS 1
A1 Thomas N. James
A1 Reginald A. Nadeau
YR 1963
UL http://jpet.aspetjournals.org/content/140/1/73.abstract
AB DCI studied by direct perfusion into the canine sinus node through its own artery has three effects on the node. First, in low concentrations it has a slight positive chronotropie effect but in higher concentrations has a negative chronotropic effect. Second, in moderate and higher concentrations DCI blocks the acceleration from adrenergic stimuli. The third effect is an associated blockade of vagal stimuli as well as of directly perfused acetylcholine, both occurring only with higher concentrations of intranodal DCI.