PT  - JOURNAL ARTICLE
AU  - J. M. Ritchie
AU  - Christine J. Armett
TI  - ON THE ROLE OF ACETYLCHOLINE IN CONDUCTION IN MAMMALIAN NONMYELINATED NERVE FIBERS
DP  - 1963 Feb 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 201--207
VI  - 139
IP  - 2
4099  - http://jpet.aspetjournals.org/content/139/2/201.short
4100  - http://jpet.aspetjournals.org/content/139/2/201.full
SO  - J Pharmacol Exp Ther1963 Feb 01; 139
AB  - Neither hexamethonium nor prostigmine in concentrations as high as 50 mM block conduction in mammalian nonmyelinated nerve fibers, although the evidence suggests that they are able to reach, and antagonize acetylcholine at, receptors in the nerve membrane when applied in very much lower concentrations. The local anesthetic dibucaine and the narcotic analgesics morphine and nalorphine have been added to the large group of compounds which are known to antagonize the depolarizing action of acetylcholine on mammalian C fibers. None of the compounds which inhibit the action of acetylcholine, with the exception of the local anesthetic dibucaine, have any marked action on the action potential. It is argued, therefore, that the evidence available does not support the theory of a physiological role of acetylcholine in axonal conduction.