RT Journal Article
SR Electronic
T1 SOME EFFECTS OF ANESTHETICS ON THE EVOKED RESPONSES IN THE AUDITORY CORTEX OF CATS
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 97
OP 106
VO 139
IS 1
A1 S. N. Pradhan
A1 Robert Galambos
YR 1963
UL http://jpet.aspetjournals.org/content/139/1/97.abstract
AB Electrical responses evoked by click from cat cortex were recorded with the help of an electronic averaging device, the effect of different anesthetics being studied in six cats. The normal response shows an initial positive wave complex usually consisting of two components, a1 and a2, separated by a negative b1 wave. This complex is followed by a negative b2 wave and a late slow positive a3 wave. In sedation or light anesthesia caused by pentobarbital the positive a1-a2 wave complex is either decreased in size or unchanged. With moderate to deep anesthesia the complex first decreases, then increases in size. In very deep anesthesia all waves disappear. Paraldehyde, ether and ethyl chloride anesthesia resemble pentobarbital in their action. Chloralose and chloroform differ from the other agents in that enhancement of both the positive wave complex and the succeeding negative wave occur more promptly, to a larger degree, and for a longer time.