RT Journal Article
SR Electronic
T1 AN ANALYSIS OF THE DEPRESSOR AND PRESSOR EFFECTS OF TRYPTAMINE IN THE CHICKEN
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 31
OP 37
VO 139
IS 1
A1 Eble, John Nelson
YR 1963
UL http://jpet.aspetjournals.org/content/139/1/31.abstract
AB The depressor effect of tryptamine in the chicken was shown to be accompanied by a rise in peripheral resistance and by a rise in right ventricular pressure. The systemic fall in pressure appeared to be the result of an acute pulmonary hypertension. It was not affected by cholinergic blockade with atropine or methylatropine, or by adrenergic blockade with tolazoline or dichloro-isoproterenol, and it was found to be reversed by the MAO inhibitor, tranylcypromine. That this vasoconstrictor action of tryptamine is not related to cholinergic or adrenergic mechanisms is indicative of the specificity of tryptamine receptors in the chicken cardiovascular system.