PT  - JOURNAL ARTICLE
AU  - John Nelson Eble
TI  - AN ANALYSIS OF THE DEPRESSOR AND PRESSOR EFFECTS OF TRYPTAMINE IN THE CHICKEN
DP  - 1963 Jan 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 31--37
VI  - 139
IP  - 1
4099  - http://jpet.aspetjournals.org/content/139/1/31.short
4100  - http://jpet.aspetjournals.org/content/139/1/31.full
SO  - J Pharmacol Exp Ther1963 Jan 01; 139
AB  - The depressor effect of tryptamine in the chicken was shown to be accompanied by a rise in peripheral resistance and by a rise in right ventricular pressure. The systemic fall in pressure appeared to be the result of an acute pulmonary hypertension. It was not affected by cholinergic blockade with atropine or methylatropine, or by adrenergic blockade with tolazoline or dichloro-isoproterenol, and it was found to be reversed by the MAO inhibitor, tranylcypromine. That this vasoconstrictor action of tryptamine is not related to cholinergic or adrenergic mechanisms is indicative of the specificity of tryptamine receptors in the chicken cardiovascular system.