RT Journal Article SR Electronic T1 EFFECTS OF ACETYLSALICYLIC ACID ON THE EDEMA AND HYPERESTHESIA OF THE EXPERIMENTALLY INFLAMED RAT'S PAW JF Journal of Pharmacology and Experimental Therapeutics JO J Pharmacol Exp Ther FD American Society for Pharmacology and Experimental Therapeutics SP 1 OP 5 VO 142 IS 1 A1 Thomas M. Gilfoil A1 Inese Klavins A1 Leonard Grumbach YR 1963 UL http://jpet.aspetjournals.org/content/142/1/1.abstract AB A study of the relationship between the degree of edema, as estimated by a volume displacement method, and the intensity of hyperesthesia to pressure to the rat's paw inflamed by injection of graded doses of brewer's yeast indicates that whereas the inflammatory hyperesthesia and edema increase with increasing doses of yeast, the relationship between the phenomena is complex. Doses of aspirin which markedly reduced the intensity of hyperesthesia did not significantly reduce the degree of attendant edema. Reduction in foot volume manifested at the higher doses of the drug may have aided the process but was not essential to it. The Williams & Wilkins Company