RT Journal Article
SR Electronic
T1 RELEASE OF AUTONOMIC MEDIATORS IN CARDIAC TISSUE BY DIRECT SUBTHRESHOLD ELECTRICAL STIMULATION
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 185
OP 194
VO 141
IS 2
A1 Frank F. Vincenzi
A1 Theodore C. West
YR 1963
UL http://jpet.aspetjournals.org/content/141/2/185.abstract
AB Electrical stimuli which are subthreshold for myocardial excitation have been shown to be effective in causing the release of autonomic mediators in several types of cardiac tissue derived from rabbit, guinea pig, dog, and cat. Strength-duration data have been presented illustrating the relative case with which subthreshold release of the autonomic mediators may be demonstrated in rabbit SA node, AV node, and left atrium. It is proposed that both subthreshold and threshold electrical stimulation act upon intramyocardial autonomic nervous elements to cause the release of acetylcholine and norepinephrine. The significance of the release of acetylchohine and/or norepinephrine in procedures involving electrical stimulation is discussed.