PT  - JOURNAL ARTICLE
AU  - Ronald Kuntzman
AU  - Martin M. Jacobson
TI  - MONOAMINE OXIDASE INHIBITION BY A SERIES OF COMPOUNDS STRUCTURALLY RELATED TO BRETYLIUM AND GUANETHIDINE
DP  - 1963 Aug 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 166--172
VI  - 141
IP  - 2
4099  - http://jpet.aspetjournals.org/content/141/2/166.short
4100  - http://jpet.aspetjournals.org/content/141/2/166.full
SO  - J Pharmacol Exp Ther1963 Aug 01; 141
AB  - The inhibition of MAO by a series of benzyl and phenethylguanidines related to bretylium and guanethidine has been studied. The most potent inhibitor is N-o-chlorobenzyl-N'N''-dimethylguanidine (B.W. 392C60) which inhibits MAO in vitro to the same extent as phenylisopropylhydrazine (PIH, JB516). This compound has been shown to be a competitive and reversible inhibitor of MAO. The significance of this MAO inhibition in the mechanism of action of these hypotensive guanidines is discussed.