@article {Kuntzman166, author = {Ronald Kuntzman and Martin M. Jacobson}, title = {MONOAMINE OXIDASE INHIBITION BY A SERIES OF COMPOUNDS STRUCTURALLY RELATED TO BRETYLIUM AND GUANETHIDINE}, volume = {141}, number = {2}, pages = {166--172}, year = {1963}, publisher = {American Society for Pharmacology and Experimental Therapeutics}, abstract = {The inhibition of MAO by a series of benzyl and phenethylguanidines related to bretylium and guanethidine has been studied. The most potent inhibitor is N-o-chlorobenzyl-N{\textquoteright}N{\textquoteright}{\textquoteright}-dimethylguanidine (B.W. 392C60) which inhibits MAO in vitro to the same extent as phenylisopropylhydrazine (PIH, JB516). This compound has been shown to be a competitive and reversible inhibitor of MAO. The significance of this MAO inhibition in the mechanism of action of these hypotensive guanidines is discussed.}, issn = {0022-3565}, URL = {https://jpet.aspetjournals.org/content/141/2/166}, eprint = {https://jpet.aspetjournals.org/content/141/2/166.full.pdf}, journal = {Journal of Pharmacology and Experimental Therapeutics} }