RT Journal Article
SR Electronic
T1 STIMULATORY EFFECT OF PHENOBARBITAL ON THE METABOLISM OF DIPHENYLHYDANTOIN
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 157
OP 160
VO 141
IS 2
A1 S. A. Cucinell
A1 R. Koster
A1 A. H. Conney
A1 J. J. Burns
YR 1963
UL http://jpet.aspetjournals.org/content/141/2/157.abstract
AB Pretreatment of dogs with phenobarbital or phetharbital increases markedly the disappearance of an intravenous dose of diphenylhydantoin. This observation is correlated with the elimination of the protective effects of diphenylhydantoin on maximal electroshock in mice that have been pretreated with phenobarbital, phetharbital or chlorcyclizine. In addition to the stimulatory effect of these drugs on diphenylhydantoin metabolism, they also stimulate the metabolism of phenylbutazone in the dog. Data are presented showing that phenylbutazone metabolism in the dog is stimulated markedly, not only by phenobarbital, phetharbital and chlorcyclizine, but by the chronic administration of phenylbutazone itself.