RT Journal Article
SR Electronic
T1 THE EFFECTS OF DIPHENYLHYDANTOIN (DILANTIN) ON SEGMENTAL AND SUPRASEGMENTAL FACILITATION AND INHIBITION OF SEGMENTAL MOTONEURONS IN THE CAT
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 84
OP 91
VO 141
IS 1
A1 Richard S. Tuttle
A1 James B. Preston
YR 1963
UL http://jpet.aspetjournals.org/content/141/1/84.abstract
AB The influence of diphenylhydantoin has been studied on certain neural pathways in both spinal and "pyramidal cat" preparations. Confirming previous studies, diphenylhydantoin was found to have no apparent effect on single-volley transmission through segmental monosynaptic reflex pathways although the phenomenon of poststimulation potentiation was depressed by the drug. In the spinal cat preparation, spatial monosynaptic facilitation and "direct" inhibition were not altered by drug injection but the pattern of influence of sural nerve volleys on extensor monosynaptic reflexes was influenced by diphenylhydantoin. In the "pyramidal cat" preparation inhibition of segmental motoneurons which was initiated by either brain stem reticular formation or motor cortex stimulation was depressed by diphenylhydantoin. Brain stem and motor cortex facilitation of segmental motoneurons was augmented by drug injection. The results of this study have been interpreted to imply that diphenylhydantoin depresses interneuronal activity and has a generalized depressing influence on both suprasegmental facilitatory and inhibitory pathways, the latter being affected quantitatively to a greater extent.