TY - JOUR T1 - RESPIRATORY RESPONSE OF GUINEA PIGS DURING ACROLEIN INHALATION AND ITS MODIFICATION BY DRUGS JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 79 LP - 83 VL - 141 IS - 1 AU - S. D. Murphy AU - D. A. Klingshirn AU - C. E. Ulrich Y1 - 1963/07/01 UR - http://jpet.aspetjournals.org/content/141/1/79.abstract N2 - The respiratory response of guinea pigs inhaling low concentrations of acrolein was characterized by an increase in total respiratory flow resistance, accompanied by decreased respiratory rates and increased tidal volumes. The magnitude of these effects increased with increasing acrolein concentrations studied, up to 1 ppm. The changes in respiratory function were reversible when the animals were returned to clean air. Atropine, aminophylline, isoproterenol and epinephrine partially or completely reversed the acrolein-induced increase in respiratory resistance, whereas tripelennamine and pyrilamine were without effect. The mechanism of increased resistance during acrolein-inhalation appears to be one of bronchoconstriction mediated through reflex cholinergic stimulation. ER -