@article {Van Der Schoot74, author = {Johan B. Van Der Schoot and Cyrus R. Creveling and Toshiharu Nagatsu and Sidney Udenfriend}, title = {ON THE MECHANISM OF INHIBITION OF DOPAMINE-β-OXIDASE BY BENZYLOXYAMINES}, volume = {141}, number = {1}, pages = {74--78}, year = {1963}, publisher = {American Society for Pharmacology and Experimental Therapeutics}, abstract = {Benzyloxyamine derivatives have been shown to be inhibitors of the enzyme dopamine-β-oxidase by virtue of their isosteric relationship to the corresponding phenethylamine derivatives. Benzyloxyamine and two hydroxylated analogues were shown to inhibit the enzyme by a mechanism which is initially competitive with substrate. However, when preincubated with the enzyme the compounds become so firmly bound that substrate cannot readily reverse the inhibition. Although preincubation results in a non-competitive type of inhibition the inhibitor-enzyme complex can, in many instances, be dissociated by prolonged dialysis.}, issn = {0022-3565}, URL = {https://jpet.aspetjournals.org/content/141/1/74}, eprint = {https://jpet.aspetjournals.org/content/141/1/74.full.pdf}, journal = {Journal of Pharmacology and Experimental Therapeutics} }