PT  - JOURNAL ARTICLE
AU  - Borgstedt, Harold H.
AU  - Benjamin, John A.
AU  - Emmel, Victor M.
TI  - THE ROLE OF HISTAMINE IN URETERAL FUNCTION
DP  - 1962 Jun 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 386--392
VI  - 136
IP  - 3
4099  - http://jpet.aspetjournals.org/content/136/3/386.short
4100  - http://jpet.aspetjournals.org/content/136/3/386.full
SO  - J Pharmacol Exp Ther1962 Jun 01; 136
AB  - Under properly controlled conditions of perfusion and pressure in vitro, histamine has a consistently stimulatory effect on canine ureteral segments. Inability of some investigators to obtain such stimulation may be ascribed to the determining role which mechanical factors play in influencing sensitivity and the type of response to histamine. The effects of histamine appear to be most readily interpreted as facilitation of the peristaltic reflex of the ureter by an action directly on the smooth muscle cells but not on the contractile mechanism itself. This, however, does not preclude the possibility that histamine plays a role in the normal function of the ureter. The effects produced by histamine, under certain conditions, can be abolished by antihistamines in concentrations which do not inhibit spontaneous contractions.