RT Journal Article
SR Electronic
T1 THE INFLUENCE OF DRUGS WHICH STIMULATE SKELETAL MUSCLE AND OF THEIR ANTAGONISTS ON FLUX OF CALCIUM, POTASSIUM AND SODIUM IONS
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 298
OP 304
VO 136
IS 3
A1 Ahmad, K.
A1 Lewis, J. J.
YR 1962
UL http://jpet.aspetjournals.org/content/136/3/298.abstract
AB In the isolated frog sartorius muscle, depolarizing and contracture-producing drugs including suxamethonium, decamethonium, nicotine, ryanodine and neostigmine increased the uptake of calcium-47 and sodium-24 but depressed that of potassium-42. Suxamethonium, nicotine, ryanodine and neostigmine also increased the release of calcium-47 and potassium-42. Decamethonium increased the release of potassium-42. Edrophonium depressed the uptake of calcium-47 and potassium-42 and increased the release of calcium-47. Carbachol increased the release of potassium-42. Protoveratrine A and protoveratrine B depressed the uptake of calcium-47. Tubocurarine and gallamine caused no change in the uptake of calcium-47, potassium-42 or sodium-24 or in the release of calcium-47 and potassium-42. It is suggested that when depolarizing or contracture-producing drugs are used, calcium ions may become more mobile being dissociated from combination with a carrier or displaced from a binding site on the cell membrane. This may break down barriers which retain, against the concentration gradients, potassium ions within and sodium ions outside the cell.