PT  - JOURNAL ARTICLE
AU  - Ahmad, K.
AU  - Lewis, J. J.
TI  - THE INFLUENCE OF DRUGS WHICH STIMULATE SKELETAL MUSCLE AND OF THEIR ANTAGONISTS ON FLUX OF CALCIUM, POTASSIUM AND SODIUM IONS
DP  - 1962 Jun 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 298--304
VI  - 136
IP  - 3
4099  - http://jpet.aspetjournals.org/content/136/3/298.short
4100  - http://jpet.aspetjournals.org/content/136/3/298.full
SO  - J Pharmacol Exp Ther1962 Jun 01; 136
AB  - In the isolated frog sartorius muscle, depolarizing and contracture-producing drugs including suxamethonium, decamethonium, nicotine, ryanodine and neostigmine increased the uptake of calcium-47 and sodium-24 but depressed that of potassium-42. Suxamethonium, nicotine, ryanodine and neostigmine also increased the release of calcium-47 and potassium-42. Decamethonium increased the release of potassium-42. Edrophonium depressed the uptake of calcium-47 and potassium-42 and increased the release of calcium-47. Carbachol increased the release of potassium-42. Protoveratrine A and protoveratrine B depressed the uptake of calcium-47. Tubocurarine and gallamine caused no change in the uptake of calcium-47, potassium-42 or sodium-24 or in the release of calcium-47 and potassium-42. It is suggested that when depolarizing or contracture-producing drugs are used, calcium ions may become more mobile being dissociated from combination with a carrier or displaced from a binding site on the cell membrane. This may break down barriers which retain, against the concentration gradients, potassium ions within and sodium ions outside the cell.