PT  - JOURNAL ARTICLE
AU  - Geller, Irving
AU  - Seifter, Joseph
TI  - THE EFFECTS OF MONO-URETHANS, DI-URETHANS AND BARBITURATES ON A PUNISHMENT DISCRIMINATION
DP  - 1962 Jun 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 284--288
VI  - 136
IP  - 3
4099  - http://jpet.aspetjournals.org/content/136/3/284.short
4100  - http://jpet.aspetjournals.org/content/136/3/284.full
SO  - J Pharmacol Exp Ther1962 Jun 01; 136
AB  - A punishment discrimination was conditioned in laboratory rats by simultaneously rewarding with food and punishing with shock all lever responses made in the presence of a discriminative stimulus (tone). Appropriate setting of the shock intensity resulted in low and stable output of responses during the tone periods. A series of central nervous system depressants was administered in order to determine degrees of attenuation of the punishment discrimination relative to the side effects of nonspecific depression. Meprobamate, a di-urethan, produced the maximum attenuation at a dose that produced a minimum of side effects. The mono-urethans hedonal, emylcamate, and urethan produced the least attenuation. Pentobarbital and phenobarbital produced intermediate attenuating effects upon the punishment discrimination.