PT  - JOURNAL ARTICLE
AU  - Benjamin Highman
AU  - Harriet M. Maling
TI  - NEUROPATHOLOGIC LESIONS IN DOGS AFTER PROLONGED ADMINISTRATION OF PHENYLISOPROPYLHYDRAZINE (JB 516) AND PHENYLISOBUTYLHYDRAZINE (JB 835)
DP  - 1962 Sep 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 344--355
VI  - 137
IP  - 3
4099  - http://jpet.aspetjournals.org/content/137/3/344.short
4100  - http://jpet.aspetjournals.org/content/137/3/344.full
SO  - J Pharmacol Exp Ther1962 Sep 01; 137
AB  - Prolonged administration of the monoamine oxidase inhibitors, phenylisopropylhydrazine (JB 516) and phenylisobutyilhydrazine (JB 835), produced bilaterally symmetrical neuropathologic lesions involving the inferior olivary nucleus and, less frequently, the pyriform lobe, particularly the amygdaloid nuclei. In the inferior olivary nucleus, many neurons had a vacuolated cytoplasm. The lesions in the pyriform lobe had many microscopie features suggesting infarction. No such neuropathologic lesions were found in cats, rabbits, and squirrel monkeys given these two hydrazine inhibitors, and no such lesions were found in dogs following prolonged administrations of other monoamine oxidase inhibitors. Proloisged administration of the two hydrazise inhsibitors caused in some dogs and other animnals testicular degenerations and huemolytic effects evidenced by a drop in hematocrit, an increase in hemosiderin deposition in the reticuloendothehial cells of the liver and spleen and occasionally by slightly increased cellularity of the bone marrow. These effects are considered to be nonspecific anti unrelated to the brain lesions.