PT  - JOURNAL ARTICLE
AU  - J. E. Baer
AU  - A. V. Brooks
AU  - R. M. Noll
AU  - Karl H. Beyer
TI  - EFFECT OF HYDROCHLOROTHIAZIDE ON RENAL ELECTROLYTE GRADIENT IN GLUCOSE DIURESIS AND EXPERIMENTAL DIABETES INSIPIDUS
DP  - 1962 Sep 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 319--323
VI  - 137
IP  - 3
4099  - http://jpet.aspetjournals.org/content/137/3/319.short
4100  - http://jpet.aspetjournals.org/content/137/3/319.full
SO  - J Pharmacol Exp Ther1962 Sep 01; 137
AB  - Hydrochlorothiazide (100 mg/kg, i.v.) did not affect the renal electrolyte gradient in uninfused dogs. The renal electrolyte gradient was obliterated by infusion of 5% glucose alone (10 ml/min). Renal medullary sodium fell from 225 to 68 mEq/liter. The gradient was not re-established upon concurrent administration of hydrochlorothiazide. An essentially normal renal sodium gradient was present in rats with experimental diabetes insipidus. Polyuria and polydipsia were suppressed by chlorothiazide or hydrochlorothiazide with no change in the renal sodium content.