RT Journal Article
SR Electronic
T1 THE EFFECTS OF GUANETHIDINE ON THE ADRENAL MEDULLA
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 229
OP 234
VO 137
IS 2
A1 Athos, William J.
A1 McHugh, Burton P.
A1 Fineberg, S. Edwin
A1 Hilton, James G.
YR 1962
UL http://jpet.aspetjournals.org/content/137/2/229.abstract
AB The effect of guanethidine on the adrenal medullary secretion of catecholamines in dogs was studied utilizing a denervated isolated adrenal gland preparation. These results were compared to a single intravenous injection of guanethidine to intact dogs with cannulation of the adrenal vein and measurement of norepinephrine and epinephrine secretion rates. Direct perfusion of the isolated denervated adrenal gland preparation with guanethidine and histamine resulted in no effect on catecholamine secretion. Blood vessel tonus, as manifested by constant mean perfusion pressure, was unaffected by guanethidine indicating no direct action of the drug on vessel walls in this type of preparation. Guanethidine in a single intravenous dose to the intact dog preparation likewise resulted in no adrenal medullary stimulation. However, the epinephrine secretion rate was decreased by greater than 50%.