RT Journal Article
SR Electronic
T1 ADJUNCTIVE VALUE OF ORAL PROPHYLAXIS WITH THE OXIMES 2-PAM LACTATE AND 2-PAM METHANESULFONATE TO THERAPEUTIC ADMINISTRATION OF ATROPINE IN DOGS POISONED BY INHALED SARIN VAPOR
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 397
OP 399
VO 136
IS 3
A1 Crook, James W.
A1 Goodman, Alvin I.
A1 Colbourn, Joseph L.
A1 Zvirblis, Peter
A1 Oberst, Fred W.
A1 Wills, J. Henry
YR 1962
UL http://jpet.aspetjournals.org/content/136/3/397.abstract
AB The effectiveness of two oximes, 2-PAM lactate and 2-PAM methanesulfonate, administered orally prior to exposure to lethal concentrations of Sarin vapor followed by atropine treatment was studied in dogs. Both oximes were effective in protecting animals exposed to Sarin and subsequently treated with atropine. Blood oxime level at the start of exposure appears to be a determinant of eventual death or survival after exposure and subsequent treatment with a standard dose of atropine. Cholinesterase activity in red blood cells or in plasma after the exposure seems not to be related to the rate of recovery of the dog from prostration after exposure to Sarin. A blood level of oxime of 3 µg/ml is suggested for estimating in man the optimal dose and dosing schedule for oral employment of quaternary 2-formylpyridine oximes to attenuate the toxic effects of inhaled organophosphorus anticholinesterases.