PT  - JOURNAL ARTICLE
AU  - Gyermek, Laszlo
AU  - Bindler, Elliot
TI  - BLOCKADE OF THE GANGLIONIC STIMULANT ACTION OF 5-HYDROXYTRYPTAMINE
DP  - 1962 Mar 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 344--348
VI  - 135
IP  - 3
4099  - http://jpet.aspetjournals.org/content/135/3/344.short
4100  - http://jpet.aspetjournals.org/content/135/3/344.full
SO  - J Pharmacol Exp Ther1962 Mar 01; 135
AB  - Evidence is obtained that 5-HT has a ganglionic stimulant action on the inferior mesenteric ganglion. The mechanism of its stimulant action is different from that of DMPP. Morphine selectively blocks the ganglionic stimulant action of 5-HT. The selectivity is less marked with cocaine and bromoLSD. Dibenzyline, benzyloxygramine and LSD do not show selectivity in blocking HT as compared with DMPP. The receptors in time inferior mesenteric ganglion sensitive to HT are different from the cholinergic receptors. Some blocking agents known as potent antagonists to 5-HT on smooth muscle organs are relatively weak and not specific for the ganglionic 5-HT receptors.