PT  - JOURNAL ARTICLE
AU  - McIsaac, Robert J.
TI  - THE RELATIONSHIP BETWEEN DISTRIBUTION AND PHARMACOLOGICAL ACTIVITY OF HEXAMETHONIUM-N-METHYL C<sup>14</sup>
DP  - 1962 Mar 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 335--343
VI  - 135
IP  - 3
4099  - http://jpet.aspetjournals.org/content/135/3/335.short
4100  - http://jpet.aspetjournals.org/content/135/3/335.full
SO  - J Pharmacol Exp Ther1962 Mar 01; 135
AB  - The distribution of C6-C14 in cats after i.v. injection was studied and correlated with its pharmacological activity. Relationships between pharmacological activity and concentration in sympathetic ganglia and in plasma were observed. There was no direct relationship between pharmacological activity and brain C6-C14 concentrations. Although C6-C14 entered most tissues rapidly, it did not diffuse out of kidney, brain and liver. There was no significant decrease in C6-C14 concentrations in these organs up to 8 hours after injection. C6-C14 was distributed primarily in extracellular fluid of all tissues except the kidney. Evidence is presented to suggest rapid entry into certain cells in the kidney. An analysis of the kinetics of disappearance of C6-C14 from various tissues showed that in the cat, tissue C6-C14 concentration is not in a simple reversible equilibrium with plasma concentration.