PT  - JOURNAL ARTICLE
AU  - Bauer, Robert O.
AU  - Free, Spencer M.
AU  - Bowen, Edward H.
TI  - MEASUREMENT OF CHRONIC PAIN RELIEF UTILIZING DOSE RESPONSE OF DEXTROMORAMIDE AGAINST MORPHINE AND PLACEBO
DP  - 1961 Mar 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 373--380
VI  - 131
IP  - 3
4099  - http://jpet.aspetjournals.org/content/131/3/373.short
4100  - http://jpet.aspetjournals.org/content/131/3/373.full
SO  - J Pharmacol Exp Ther1961 Mar 01; 131
AB  - In a double-blind experiment using patients with chronic, continuous pain, graded doses of a new analgesic, dextromoramide, were compared with 10-mg doses of morphine sulfate and physiologic sodium chloride solution. Emphasis was placed on the experimental design employed. The advantages of a design balanced to compensate for patient-to-patient effects and yet to emphasize information about the test drug are discussed. Two indices of efficacy enhance the interpretation of the results. When considering duration of relief, 10.3 mg of dextromoramide were estimated to be equivalent to 10 mg of morphine sulfate. When considering the number of doses providing more than 1.5 hours of relief, 4.9 mg of dextromoramide were estimated to be equivalent to 10 mg of morphine sulfate. Euphoria was more frequently reported with 5 and 10 mg of dextromoramide than with morphine or placebo regimens. No differences in other side effects, blood pressure, pulse, or respiratory rates were observed for comparable drug regimens.