RT Journal Article
SR Electronic
T1 EFFECT OF ETHIONINE AND CARBON TETRACHLORIDE ON URETHAN AND PHENOBARBITAL INDUCED CHANGES IN HEXOBARBITAL ACTION
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 282
OP 286
VO 131
IS 3
A1 James M. Fujimoto
A1 Gabriel L. Plaa
YR 1961
UL http://jpet.aspetjournals.org/content/131/3/282.abstract
AB The effect of ethionine and CCl4 on the urethan or phenobarbital shortening of hexobarbital sleeping time was studied in mice. If ethionine or CCl4 was given simultaneously with urethan or phenobarbital, the normally observed shortening response was blocked. If, however, ethionine or CCl4 was given 24 hours after the urethan or phenobarbital, the response was not blocked. These data are interpreted to indicate that the urethan and phenobarbital responses may be due to enzyme induction. These effects were produced with doses of ethionine and CCl4 which had no effect on normal sleeping time and bromsulfalein retention.