PT  - JOURNAL ARTICLE
AU  - James M. Fujimoto
AU  - Gabriel L. Plaa
TI  - EFFECT OF ETHIONINE AND CARBON TETRACHLORIDE ON URETHAN AND PHENOBARBITAL INDUCED CHANGES IN HEXOBARBITAL ACTION
DP  - 1961 Mar 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 282--286
VI  - 131
IP  - 3
4099  - http://jpet.aspetjournals.org/content/131/3/282.short
4100  - http://jpet.aspetjournals.org/content/131/3/282.full
SO  - J Pharmacol Exp Ther1961 Mar 01; 131
AB  - The effect of ethionine and CCl4 on the urethan or phenobarbital shortening of hexobarbital sleeping time was studied in mice. If ethionine or CCl4 was given simultaneously with urethan or phenobarbital, the normally observed shortening response was blocked. If, however, ethionine or CCl4 was given 24 hours after the urethan or phenobarbital, the response was not blocked. These data are interpreted to indicate that the urethan and phenobarbital responses may be due to enzyme induction. These effects were produced with doses of ethionine and CCl4 which had no effect on normal sleeping time and bromsulfalein retention.