RT Journal Article
SR Electronic
T1 POTENCY OF THIOPENTAL PLUS β,β-ETHYLMETHYLGLUTARIMIDE
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 364
OP 366
VO 130
IS 3
A1 J. Weldon Bellville
A1 Terence Murphy
A1 William S. Howland
YR 1960
UL http://jpet.aspetjournals.org/content/130/3/364.abstract
AB The potency ratio of thiopental and a 3:1 mixture of thiopental + β,β-ethylmethylglutarimide has been determined in seven dogs by a servo-controlled, cross-over experiment employing the electroencephalogram as an index of drug action. Thiopental was found to be 1.51 times as potent as thiopental plus β,β-ethylmethylglutarimide. The upper and lower 95% confidence limits were 2.3 and 1.1, respectively.